Carbon-negative synthetic biology: challenges and emerging trends of cyanobacterial technology

C Tan, P Xu, F Tao - Trends in biotechnology, 2022 - cell.com
Global warming and climate instability have spurred interest in using renewable carbon
resources for the sustainable production of chemicals. Cyanobacteria are ideal cellular …

Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Scarless wound healing programmed by core-shell microneedles

Y Zhang, S Wang, Y Yang, S Zhao, J You… - Nature …, 2023 - nature.com
Effective reprogramming of chronic wound healing remains challenging due to the limited
drug delivery efficacy hindered by physiological barriers, as well as the inappropriate dosing …

Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy

L Yang, D Zhang, W Li, H Lin, C Ding, Q Liu… - Nature …, 2023 - nature.com
The treatment of diabetic wounds faces enormous challenges due to complex wound
environments, such as infected biofilms, excessive inflammation, and impaired …

Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections

W Xiu, L Wan, K Yang, X Li, L Yuwen, H Dong… - Nature …, 2022 - nature.com
Traditional antibiotic treatment has limited efficacy for the drug-tolerant bacteria present in
biofilms because of their unique metabolic conditions in the biofilm infection …

Guidelines on diagnosis, prognosis, and management of peripheral artery disease in patients with foot ulcers and diabetes (IWGDF 2019 update)

RJ Hinchliffe, RO Forsythe, J Apelqvist… - Diabetes/metabolism …, 2020 - Wiley Online Library
Abstract The International Working Group on the Diabetic Foot (IWGDF) has published
evidence‐based guidelines on the prevention and management of diabetic foot disease …

Dissolved oxygen from microalgae-gel patch promotes chronic wound healing in diabetes

H Chen, Y Cheng, J Tian, P Yang, X Zhang, Y Chen… - Science …, 2020 - science.org
Chronic wounds in diabetes undergo a lifetime risk of developing into diabetic foot ulcers.
Oxygen is crucial to wound healing by regulating cell proliferation, migration, and …

Programmed microalgae-gel promotes chronic wound healing in diabetes

Y Kang, L Xu, J Dong, X Yuan, J Ye, Y Fan… - Nature …, 2024 - nature.com
Chronic diabetic wounds are at lifelong risk of developing diabetic foot ulcers owing to
severe hypoxia, excessive reactive oxygen species (ROS), a complex inflammatory …

Risk factors for lower extremity amputation in patients with diabetic foot ulcers: A meta-analysis

C Lin, J Liu, H Sun - PloS one, 2020 - journals.plos.org
Purpose A considerable number of diabetic foot ulcer (DFU) patients require amputation
every year, which worsens their quality of life, aggravates the social burden, and shortens …

Symbiotic algae–bacteria dressing for producing hydrogen to accelerate diabetic wound healing

H Chen, Y Guo, Z Zhang, W Mao, C Shen, W Xiong… - Nano Letters, 2021 - ACS Publications
Oxidative stress induced by hyperglycemia or chronic inflammation can limit diabetic wound
healing, resulting in diabetic foot ulcers. Hydrogen has the potential to act as an antioxidant …