Inhibitors of apoptosis (IAPs) are a family of proteins that play a significant role in the control
of programmed cell death (PCD). PCD is essential to maintain healthy cell turnover within …

Mitochondria have emerged as important pharmacological targets because of their key role
in cellular proliferation and death. In tumor tissues, mitochondria can switch metabolic …

Background Debio 1143 is an orally available antagonist of inhibitor of apoptosis proteins
with the potential to enhance the antitumour activity of cisplatin and radiotherapy. The …

Simple Summary The Inhibitor of Apoptosis (IAP) family of proteins has emerged as a
potential pharmacological target in cancer. Abnormal expression of IAPs can lead to …

It is well accepted that the ability of cancer cells to circumvent the cell death program that
untransformed cells are subject to helps promote tumor growth. Strategies designed to …

Abstract The Cancer Genome Atlas (TCGA) has unveiled genomic deregulation of various
components of the extrinsic and intrinsic apoptotic pathways in different types of cancers …

Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular
process to eliminate unwanted or damaged cells. Resistance of apoptosis is a hallmark of …

Xevinapant is a first-in-class antagonist of inhibitor of apoptosis proteins, which enhances
cancer cell sensitivity to chemotherapy and radiotherapy. In a phase II randomized study in …

One of the hallmarks of cancer cells is their ability to evade cell death via apoptosis. The
inhibitor of apoptosis proteins (IAPs) are a family of proteins that act to promote cell survival …

Chemoradiotherapy (CRT) remains the standard treatment for locally advanced head and
neck squamous cell carcinoma (LA-HNSCC), based on numerous randomized controlled …