Immune processes have a vital role in CNS homeostasis, resilience and brain reserve. Our
cognitive and social abilities rely on a highly sensitive and fine-tuned equilibrium of immune …

Crosstalk between inflammatory pathways and neurocircuits in the brain can lead to
behavioural responses, such as avoidance and alarm, that are likely to have provided early …

Resilience is the process that allows individuals to adapt to adverse conditions and recover
from them. This process is favored by individual qualities that have been amply studied in …

Stress-related neuropsychiatric disorders, such as major depressive disorder and
posttraumatic stress disorder, exact enormous socioeconomic and individual consequences …

Physical or mental stress leads to neuroplasticity in the brain and increases the risk of
depression and anxiety. Stress exposure causes the dysfunction of peripheral T …

Diagnostic criteria for mood disorders including major depressive disorder (MDD) largely
ignore biological factors in favor of behavioral symptoms. Compounding this paucity of …

The potential contribution of chronic inflammation to the development of neuropsychiatric
disorders such as major depression has received increasing attention. Elevated biomarkers …

The relationship between disease and good health has received relatively little attention in
mental health. Resilience can be viewed as a defence mechanism, which enables people to …

Much of the current understanding about the pathogenesis of altered mood, impaired
concentration and neurovegetative symptoms in major depression has come from animal …

The chronic mild (or unpredictable/variable) stress (CMS) model was developed as an
animal model of depression more than 20 years ago. The foundation of this model was that …