The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Ubiquitination plays a central role in the regulation of various biological functions including
immune responses. Ubiquitination is induced by a cascade of enzymatic reactions by E1 …

DNA double-strand breaks (DSBs) elicit a histone modification cascade that controls DNA
repair,,. This pathway involves the sequential ubiquitination of histones H1 and H2A by the …

Branched ubiquitin (Ub) chains constitute a sizable fraction of Ub polymers in human cells.
Despite their abundance, our understanding of branched Ub function in cell signaling has …

Conjugation and deconjugation of ubiquitin and ubiquitin-like proteins (Ubls) to cellular
proteins are highly regulated processes integral to cellular homeostasis. Most often, the C …

Mutations in PINK 1 and PARKIN cause recessive, early‐onset Parkinson's disease (PD).
Together, these two proteins orchestrate a protective mitophagic response that ensures the …

Polyubiquitylation is canonically viewed as a posttranslational modification that governs
protein stability or protein-protein interactions, in which distinct polyubiquitin linkages …

Post-translational modifications (PTMs) by ubiquitin (Ub) are versatile, highly dynamic, and
involved in nearly all aspects of eukaryote biological function. The reversibility and …

In this review, we focus on the ubiquitination process within the endoplasmic reticulum
associated protein degradation (ERAD) pathway. Approximately one third of all synthesized …

Ubiquitination is one of the most utilized posttranslational modifications in eukaryotes and is
involved in a wide range of cellular processes, but is mostly known as a signal for …