Recent developments for the deuterium and tritium labeling of organic molecules

S Kopf, F Bourriquen, W Li, H Neumann… - Chemical …, 2022 - ACS Publications
Organic compounds labeled with hydrogen isotopes play a crucial role in numerous areas,
from materials science to medicinal chemistry. Indeed, while the replacement of hydrogen by …

C–H deuteration of organic compounds and potential drug candidates

G Prakash, N Paul, GA Oliver, DB Werz… - Chemical Society …, 2022 - pubs.rsc.org
C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

Recent advances in the synthesis of deuterium‐labeled compounds

X Yang, H Ben, AJ Ragauskas - Asian Journal of Organic …, 2021 - Wiley Online Library
Deuterium‐labeled compounds are of importance in chemical, environmental, and
biological fields. Preparation methods for deuterium‐labeled compounds have been studied …

Molybdenum-mediated reductive deuteration of nitroarenes with D 2 O: synthesis of ortho-and para-deuterated anilines

JL Lu, JT Deng, M Lang, JB Peng - Organic Chemistry Frontiers, 2024 - pubs.rsc.org
A unique and practical molybdenum-mediated reductive deuteration of nitroarenes for the
selective synthesis of ortho-and para-deuterated anilines has been developed. Using Mo …

Remote Site-Selective C(sp3)–H Monodeuteration of Unactivated Alkenes via Chain-Walking Strategy

H Song, W Zhang, H Zhou, J Wei, X Cai, F Yang… - ACS …, 2023 - ACS Publications
The installation of deuterium atoms at distal C (sp3)–H bonds is a longstanding synthetic
challenge. Through the synergistic combination of chain-walking strategy and transfer …

Multiple site hydrogen isotope labelling of pharmaceuticals

M Daniel‐Bertrand, S Garcia‐Argote… - Angewandte Chemie …, 2020 - Wiley Online Library
Radiolabelling is fundamental in drug discovery and development as it is mandatory for
preclinical ADME studies and late‐stage human clinical trials. Herein, a general, effective …

Manganese‐Catalysed Deuterium Labelling of Anilines and Electron‐Rich (Hetero) Arenes

F Bourriquen, N Rockstroh, S Bartling… - Angewandte Chemie …, 2022 - Wiley Online Library
There is a constant need for deuterium‐labelled products for multiple applications in life
sciences and beyond. Here, a new class of heterogeneous catalysts is reported for practical …

Hydrogen/deuterium exchange mass spectrometry in the world of small molecules

A Damont, A Legrand, C Cao… - Mass Spectrometry …, 2023 - Wiley Online Library
The combined use of hydrogen/deuterium exchange (HDX) and mass spectrometry (MS),
referred to as HDX‐MS, is a powerful tool for exploring molecular edifices and has been …

Ir-Catalyzed Ortho-Selective C–H Borylation of Difluoromethyl Arenes

CY Li, Z Zhang, X Yan - Organic Letters, 2023 - ACS Publications
The difluoromethyl group (CF2H) has received great attention due to its distinct properties in
recent years. Herein, we report a new strategy for postmodification of difluoromethyl …

Synthesis of β-Deuterated Amino Acids via Palladium-Catalyzed H/D Exchange

FF Sheng, JG Gu, KH Liu… - The Journal of Organic …, 2022 - ACS Publications
Despite several synthetic approaches that have been developed for α-deuterated amino
acids, the synthesis of β-deuterated amino acids has remained a challenge. Herein, we …