Mast cells have crucial roles in allergic and other inflammatory diseases. Preclinical
approaches provide circumstantial evidence for mast cell involvement in many diseases, but …

Mast cells are immune cells of the haematopoietic lineage that are now thought to have
multifaceted functions during homeostasis and in various disease states. Furthermore, while …

Irritable bowel syndrome (IBS) remains one of the most common gastrointestinal disorders
seen by clinicians in both primary and secondary care. Since publication of the last British …

Alterations in the gut microbiome, including diet-driven changes, are linked to the rising
prevalence of food allergy. However, little is known about how specific gut bacteria trigger …

In addition to its canonical function of protection from pathogens, the immune system can
also alter behaviour,. The scope and mechanisms of behavioural modifications by the …

The physiological functions of mast cells remain largely an enigma. In the context of barrier
damage, mast cells are integrated in type 2 immunity and, together with immunoglobulin E …

A highly conserved but convoluted network of neurons and glial cells, the enteric nervous
system (ENS), is positioned along the wall of the gut to coordinate digestive processes and …

Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder that is
characterized by abdominal pain and an altered defecation pattern. It affects between 5 and …

Functional gastrointestinal disorders (FGIDs) have been re-named as disorders of gut-brain
interactions. These conditions are not only common in clinical practice, but also in the …

Functional gastrointestinal disorders—recently renamed into disorders of gut–brain
interaction—such as irritable bowel syndrome and functional dyspepsia are highly prevalent …