Vaccines for human fungal diseases: close but still a long way to go

LVN Oliveira, R Wang, CA Specht, SM Levitz - npj Vaccines, 2021 - nature.com
Despite the substantial global burden of human fungal infections, there are no approved
fungal vaccines to protect at risk individuals. Here, we review the progress that has been …

Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants

X Li, R Xing, C Xu, S Liu, Y Qin, K Li, H Yu, P Li - Carbohydrate polymers, 2021 - Elsevier
Vaccines have always been the most effective preventive treatment. Advancements in the
field of vaccine is inseparable from adjuvants. Adjuvants are substances added to vaccines …

Immunological correlates of protection following vaccination with glucan particles containing Cryptococcus neoformans chitin deacetylases

R Wang, LVN Oliveira, D Lourenco, CL Gomez, CK Lee… - npj Vaccines, 2023 - nature.com
Vaccination with glucan particles (GP) containing the Cryptococcus neoformans chitin
deacetylases Cda1 and Cda2 protect mice against experimental cryptococcosis. Here …

[HTML][HTML] Efficacy and safety of immunological adjuvants. Where is the cut-off?

A Batista-Duharte, DT Martínez, IZ Carlos - Biomedicine & …, 2018 - Elsevier
Research over the past several decades has provided insight into the mode of action of
adjuvants. However, the main focus of attention has been the efficacy in the induction of …

[HTML][HTML] Prophylaxis and therapeutic ability of inactivated dermatophytic vaccine against dermatophytosis in the rabbits as an animal model

AAHS Al-Janabi, FHO Al-Khikani - Turkish Journal of …, 2021 - ncbi.nlm.nih.gov
Objectives: Dermatophytosis is a group of cutaneous diseases widely distributed in human
and animals. It causes serious infection in some human cases and economic losses in farm …

Specific Focus on Antifungal Peptides against Azole Resistant Aspergillus fumigatus: Current Status, Challenges, and Future Perspectives

DA Pimienta, FE Cruz Mosquera, I Palacios Velasco… - Journal of Fungi, 2022 - mdpi.com
The prevalence of fungal infections is increasing worldwide, especially that of aspergillosis,
which previously only affected people with immunosuppression. Aspergillus fumigatus can …

The hen's egg test on chorioallantoic membrane: An alternative assay for the assessment of the irritating effect of vaccine adjuvants

A Batista-Duharte, G Jorge Murillo… - International …, 2016 - journals.sagepub.com
Local reactions are the most frequent adverse event associated with vaccines. Adjuvants are
major constituents of many vaccines and they are frequently involved in these reactions …

[HTML][HTML] New insights on the development of fungal vaccines: from immunity to recent challenges

NP Medici, M Del Poeta - Memórias do Instituto Oswaldo Cruz, 2015 - SciELO Brasil
Fungal infections are emerging as a major problem in part due to high mortality associated
with systemic infections, especially in the case of immunocompromised patients. With the …

T cell responses to control fungal infection in an immunological memory lens

J Sharma, S Mudalagiriyappa… - Frontiers in …, 2022 - frontiersin.org
In recent years, fungal vaccine research emanated significant findings in the field of
antifungal T-cell immunity. The generation of effector T cells is essential to combat many …

A cell wall protein-based vaccine candidate induce protective immune response against Sporothrix schenckii infection

DL Portuondo, A Batista-Duharte, LS Ferreira… - Immunobiology, 2016 - Elsevier
Sporotrichosis is a subcutaneous mycosis caused by several closely related thermo-
dimorphic fungi of the Sporothrix schenckii species complex, affecting humans and other …