Role of TLRs in HIV-1 infection and potential of TLR agonists in HIV-1 vaccine development and treatment strategies

M Rozman, S Zidovec-Lepej, K Jambrosic, M Babić… - Pathogens, 2023 - mdpi.com
Toll-like receptors (TLRs), as a family of pattern recognition receptors, play an important role
in the recognition of HIV-1 molecular structures by various cells of the innate immune …

Defensin gene variation and HIV/AIDS: a comprehensive perspective needed

RK Mehlotra, PA Zimmerman… - Journal of Leucocyte …, 2016 - academic.oup.com
Both α-and β-defensins have anti–human immunodeficiency virus activity. These defensins
achieve human immunodeficiency virus inhibition through a variety of mechanisms …

Effect of TLR10 (2322A/G, 720A/C, and 992T/A) polymorphisms on the pathogenesis of Crimean Congo hemorrhagic fever disease

S Kızıldağ, S Arslan, N Özbilüm… - Journal of Medical …, 2018 - Wiley Online Library
Crimean Congo hemorrhagic fever (CCHF) is a tick‐borne disease caused by the Crimean
Congo hemorrhagic fever virus (CCHFV). Toll‐like receptors (TLRs) are type 1 …

Endosomal toll-like receptor gene polymorphisms and susceptibility to HIV and HCV co-infection–Differential influence in individuals with distinct ethnic background

JM Valverde-Villegas, BP Dos Santos… - Human Immunology, 2017 - Elsevier
The genetic background of human populations can influence the susceptibility and outcome
of infection diseases. Toll-like receptors (TLRs) have been previously associated with …

Effects of TLR7 polymorphisms on the susceptibility and progression of HIV-1 infection in Chinese MSM population

T Zhang, J Zhu, B Su, L Cao, Z Li, H Wei… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptor (TLR) 7 plays a key role in innate and adaptive immunity for HIV-1
infection. We evaluated the effect of TLR7 polymorphisms on disease susceptibility and …

Single nucleotide polymorphisms in genes encoding toll-like receptors 7 and 8 and their association with proviral load of SRLVs in goats of polish carpathian breed

M Olech, K Ropka-Molik, T Szmatoła, K Piórkowska… - Animals, 2021 - mdpi.com
Simple Summary The purpose of the study was to identify SNPs in genes encoding TLR7
and TLR8 in goats of Carpathian breed and analyze their association with the SRLVs …

Alteration of antiviral signalling by single nucleotide polymorphisms (SNPs) of mitochondrial antiviral signalling protein (MAVS)

F Xing, T Matsumiya, R Hayakari, H Yoshida… - PloS one, 2016 - journals.plos.org
Genetic variation is associated with diseases. As a type of genetic variation occurring with
certain regularity and frequency, the single nucleotide polymorphism (SNP) is attracting …

TLR genetic variation is associated with Rotavirus–specific IgA seroconversion in South African Black infants after two doses of Rotarix vaccine

TV Miya, MJ Groome, D de Assis Rosa - Vaccine, 2021 - Elsevier
Live oral rotavirus vaccines have significantly reduced rotavirus-related diarrheal morbidity
and mortality globally, but low efficacy of these vaccines is observed in low–income …

CCR5∆ 32 and SDF1 3′ A: Gene Variants, Expression and Influence on Biological Markers for the Clinical Progression to AIDS among HIV-1 Virus Controllers in a …

ÉRG Lima, MAF Queiroz, SS Lima… - International Journal of …, 2023 - mdpi.com
CCR5Δ32 and SDF1-3′ A polymorphisms were investigated in a cohort of viremia
controllers, without the use of therapy, along with their influence on CD4+ T lymphocytes …

CCR2, CCR5, and CXCL12 variation and HIV/AIDS in Papua New Guinea

RK Mehlotra, NB Hall, SE Bruse, B John… - Infection, Genetics and …, 2015 - Elsevier
Polymorphisms in chemokine receptors, serving as HIV co-receptors, and their ligands are
among the well-known host genetic factors associated with susceptibility to HIV infection …