Coronary heart disease (CHD) is the leading cause of morbidity and mortality world-wide
and has been characterized as a chronic immunoinflammatory, fibroproliferative disease …

Nitric oxide (NO·) is an important protective molecule in the vasculature, and endothelial NO·
synthase (eNOS) is responsible for most of the vascular NO· produced. A functional eNOS …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Advances in omics technologies now allow an unprecedented level of phenotyping for
human diseases, including obesity, in which individual responses to excess weight are …

Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated
with atherosclerosis and is therefore held to be an early feature in atherogenesis. However …

Cyclic guanosine 3', 5'-monophosphate (cGMP) mediates a wide spectrum of physiologic
processes in multiple cell types within the cardiovascular system. Dysfunctional signaling at …

The incidence of obesity is increasing at an alarming rate. There is compelling evidence that
obesity increases the risk of preeclampsia about three-fold, and in developed countries is …

Endothelial nitric oxide synthase (eNOS) serves as a critical enzyme in maintaining vascular
pressure by producing nitric oxide (NO); hence, it has a crucial role in the regulation of …

Vascular nitric oxide (NO•) resistance, manifested by an impaired vasodilator function of NO•
in both the macro-and microvessels, is a common state in type 2 diabetes (T2D) associated …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …