PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
piRNA-guided genome defense: from biogenesis to silencing
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …
Split-TurboID enables contact-dependent proximity labeling in cells
Proximity labeling catalyzed by promiscuous enzymes, such as TurboID, have enabled the
proteomic analysis of subcellular regions difficult or impossible to access by conventional …
proteomic analysis of subcellular regions difficult or impossible to access by conventional …
Restricting retrotransposons: a review
JL Goodier - Mobile DNA, 2016 - Springer
Retrotransposons have generated about 40% of the human genome. This review examines
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
the strategies the cell has evolved to coexist with these genomic “parasites”, focussing on …
One loop to rule them all: the ping-pong cycle and piRNA-guided silencing
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …
the genetic information of animal germ cells from the deleterious effects of molecular …
[HTML][HTML] Variant PNLDC1, Defective piRNA Processing, and Azoospermia
L Nagirnaja, N Mørup, JE Nielsen… - … England Journal of …, 2021 - Mass Medical Soc
Background P-element–induced wimpy testis (PIWI)–interacting RNAs (piRNAs) are short
(21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ …
(21 to 35 nucleotides in length) and noncoding and are found almost exclusively in germ …
RISC assembly: Coordination between small RNAs and Argonaute proteins
H Kobayashi, Y Tomari - Biochimica et Biophysica Acta (BBA)-Gene …, 2016 - Elsevier
Non-coding RNAs generally form ribonucleoprotein (RNP) complexes with their partner
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
proteins to exert their functions. Small RNAs, including microRNAs, small interfering RNAs …
Whole-exome sequencing improves the diagnosis and care of men with non-obstructive azoospermia
ZE Kherraf, C Cazin, A Bouker, SFB Mustapha… - The American Journal of …, 2022 - cell.com
Non-obstructive azoospermia (NOA) is a severe and frequent cause of male infertility, often
treated by testicular sperm extraction followed by intracytoplasmic sperm injection. The aim …
treated by testicular sperm extraction followed by intracytoplasmic sperm injection. The aim …
piRNAs: from biogenesis to function
EM Weick, EA Miska - Development, 2014 - journals.biologists.com
Distinguishing self from non-self plays a crucial role in safeguarding the germlines of
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
metazoa from mobile DNA elements. Since their discovery less than a decade ago, Piwi …
piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production
PIWI-interacting RNAs (piRNAs) protect the animal germ line by silencing transposons.
Primary piRNAs, generated from transcripts of genomic transposon “junkyards”(piRNA …
Primary piRNAs, generated from transcripts of genomic transposon “junkyards”(piRNA …