Gene regulatory networks drive the specific transcriptional programmes responsible for the
diversification of cell types during the development of multicellular organisms. Although our …

In female eutherian mammals, dosage compensation of X-linked gene expression is
achieved during development through transcriptional silencing of one of the two X …

Recent advances in single-cell sequencing technologies have enabled simultaneous
measurement of multiple cellular modalities, but the combined detection of histone post …

In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

In eukaryotic nuclei, most genes are transcribed by RNA polymerase II (RNAP2), whose
regulation is a key to understanding the genome and cell function. RNAP2 has a long …

The properties of cancer stem cells (CSCs), such as self-renewal, drug resistance, and
metastasis, have been indicated to be responsible for the poor prognosis of patients with …

During decidualization in rodents, uterine stroma undergoes extensive reprograming into
distinct cells, forming the discrete regions defined as the primary decidual zone (PDZ), the …

Facultative heterochromatin controls development and differentiation in many eukaryotes. In
metazoans, plants, and many filamentous fungi, facultative heterochromatin is characterized …

Abnormalities in chromosome dose can reduce organismal fitness and viability by disrupting
the balance of gene expression. Unlike imbalances in chromosome dose that cause …

Abnormalities in chromosome number have the potential to disrupt the balance of gene
expression and thereby decrease organismal fitness and viability. Such abnormalities occur …