The treatment of long-gap (> 10 mm) peripheral nerve injury (PNI) and spinal cord injury
(SCI) remains a continuous challenge due to limited native tissue regeneration capabilities …

Advances in biomedical research have generated an unprecedented number of potential
targets for therapeutic intervention to treat disease or delay disease progression …

Exosomes are the most extensively characterized class of secreted membrane vesicles that
carry proteins and RNAs for intercellular communication. They are increasingly seen as …

Mesenchymal stem cells (MSC) derived from bone marrow can potentially reduce the acute
inflammatory response in spinal cord injury (SCI) and thus promote functional recovery …

The low regeneration potential of the central nervous system (CNS) represents a challenge
for the development of new therapeutic strategies. Mesenchymal stem cells (MSCs) have …

With technological advances in basic research, the intricate mechanism of secondary
delayed spinal cord injury (SCI) continues to unravel at a rapid pace. However, despite our …

Spinal cord injury (SCI) is a devastating condition producing great personal and societal
costs and for which there is no effective treatment. Stem cell transplantation is a promising …

Spinal cord injury (SCI) is an as yet untreatable neuropathology that causes severe
dysfunction and disability. Cell-based therapies hold neuroregenerative and neuroprotective …

Background Exosomes derived from the bone marrow mesenchymal stem cell (MSC) have
shown great potential in spinal cord injury (SCI) treatment. This research was designed to …

BACKGROUND: In our previous report, 3 of 10 patients with spinal cord injury who were
injected with autologous mesenchymal stem cells (MSCs) showed motor improvement in the …