[HTML][HTML] The search for novel analgesics: targets and mechanisms

TL Yaksh, SA Woller, R Ramachandran… - F1000prime …, 2015 - ncbi.nlm.nih.gov
The management of the pain state is of great therapeutic relevance to virtually every medical
specialty. Failure to manage its expression has deleterious consequence to the well-being …

2022 WSAVA guidelines for the recognition, assessment and treatment of pain

BP Monteiro, BDX Lascelles, J Murrell… - Journal of Small …, 2023 - Wiley Online Library
Animal sentience refers to the capacity of animals to feel both positive and negative
emotions including that of pain. As veterinary health professionals, we have a medical and …

The short form of the Glasgow composite measure pain scale in post-operative analgesia studies in dogs: a scoping review

B Testa, J Reid, ME Scott, PJ Murison… - Frontiers in Veterinary …, 2021 - frontiersin.org
The measurement and treatment of acute pain in animals is essential from a welfare
perspective. Valid pain-related outcome measures are also crucial for ensuring reliable and …

2015 AAHA/AAFP pain management guidelines for dogs and cats

ME Epstein, I Rodanm, G Griffenhagen… - Journal of feline …, 2015 - journals.sagepub.com
Rationale: The robust advances in pain management for companion animals underlie the
decision of the American Animal Hospital Association (AAHA) and American Association of …

A comprehensive tool box for large animal studies of intervertebral disc degeneration

NN Lee, E Salzer, FC Bach, AF Bonilla, JL Cook… - JOR …, 2021 - Wiley Online Library
Preclinical studies involving large animal models aim to recapitulate the clinical situation as
much as possible and bridge the gap from benchtop to bedside. To date, studies …

Psychometric assessment of the Rat Grimace Scale and development of an analgesic intervention score

V Oliver, D De Rantere, R Ritchie, J Chisholm… - PLoS …, 2014 - journals.plos.org
Our limited ability to assess spontaneous pain in rodent models of painful human conditions
may be associated with a translational failure of promising analgesic compounds in to …

Real-time application of the Rat Grimace Scale as a welfare refinement in laboratory rats

V Leung, E Zhang, DSJ Pang - Scientific reports, 2016 - nature.com
Rodent grimace scales have been recently validated for pain assessment, allowing
evaluation of facial expressions associated with pain. The standard scoring method is …

Current status and future directions of botulinum neurotoxins for targeting pain processing

S Pellett, TL Yaksh, R Ramachandran - Toxins, 2015 - mdpi.com
Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into
peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise …

Gabapentin as an adjuvant for postoperative pain management in dogs undergoing mastectomy

GC Crociolli, RN Cassu, RC Barbero… - Journal of Veterinary …, 2015 - jstage.jst.go.jp
This study aimed to evaluate the analgesic efficacy of gabapentin as an adjuvant for
postoperative pain management in dogs. Twenty dogs undergoing mastectomy were …

Postoperative pain behaviours in rabbits following orthopaedic surgery and effect of observer presence

RH Pinho, MC Leach, BW Minto, FDL Rocha… - PloS one, 2020 - journals.plos.org
Rabbits are widely used in studies focusing on pain. However, pain is undertreated in this
species and one possible factor to explain this is the lack of evaluation methods. The …