Artificial intelligence in cancer target identification and drug discovery
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …
novel drugs from biology networks because the networks can effectively preserve and …
A guide to conquer the biological network era using graph theory
Networks are one of the most common ways to represent biological systems as complex sets
of binary interactions or relations between different bioentities. In this article, we discuss the …
of binary interactions or relations between different bioentities. In this article, we discuss the …
hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data
Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …
functional units based on tightly regulated interactions between distinct molecules, cells …
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia
Acute myeloid leukemia (AML) is a cancer of myeloid-lineage cells with limited therapeutic
options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and …
options. We previously combined ex vivo drug sensitivity with genomic, transcriptomic, and …
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
The genetic circuits that allow cancer cells to evade destruction by the host immune system
remain poorly understood,–. Here, to identify a phenotypically robust core set of genes and …
remain poorly understood,–. Here, to identify a phenotypically robust core set of genes and …
Proteomics analysis of plasma from middle-aged adults identifies protein markers of dementia risk in later life
A diverse set of biological processes have been implicated in the pathophysiology of
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Alzheimer's disease (AD) and related dementias. However, there is limited understanding of …
Gut microbially produced indole-3-propionic acid inhibits atherosclerosis by promoting reverse cholesterol transport and its deficiency is causally related to …
H Xue, X Chen, C Yu, Y Deng, Y Zhang… - Circulation …, 2022 - Am Heart Assoc
Background: Accumulating evidence has shown that disorders in the gut microbiota and
derived metabolites affect the development of atherosclerotic cardiovascular disease …
derived metabolites affect the development of atherosclerotic cardiovascular disease …
[HTML][HTML] The global phosphorylation landscape of SARS-CoV-2 infection
M Bouhaddou, D Memon, B Meyer, KM White… - Cell, 2020 - cell.com
The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed …
RNA-Seq signatures normalized by mRNA abundance allow absolute deconvolution of human immune cell types
The molecular characterization of immune subsets is important for designing effective
strategies to understand and treat diseases. We characterized 29 immune cell types within …
strategies to understand and treat diseases. We characterized 29 immune cell types within …
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
T Lohoff, S Ghazanfar, A Missarova, N Koulena… - Nature …, 2022 - nature.com
Molecular profiling of single cells has advanced our knowledge of the molecular basis of
development. However, current approaches mostly rely on dissociating cells from tissues …
development. However, current approaches mostly rely on dissociating cells from tissues …