The side effects of cancer therapy continue to cause significant health and cost burden to the
patient, their friends and family, and governments. A major barrier in the way in which these …

The 'entourage effect'term was originally coined in a pre-clinical study observing
endogenous bio-inactive metabolites potentiating the activity of a bioactive …

Importance Patients with chronic pain often receive long-term opioid therapy (LOT), which
places them at risk of opioid use disorder and overdose. This presents the need for …

The opioid and cannabinoid receptor systems are inextricably linked—overlapping at the
anatomical, functional and behavioural levels. Preclinical studies have reported that …

While effective in treating abdominal pain, opioids have significant side effects. Recent
legalization of cannabis will likely promote use of cannabinoids as an adjunct or alternative …

Introduction There is growing evidence on the efficacy of cannabis-based medicinal
products (CBMPs) for chronic pain (CP). Due to the interaction between CP and anxiety, and …

Introduction In light of the widespread use of non-prescribed and prescribed cannabidiol, the
use of cannabidiol with other medications is likely, and this may result in drug interactions …

Interest in medical cannabis and cannabis-based medicinal products (CBMPs) has
increased greatly in recent years. Two cannabinoids are of principal importance; delta-9 …

The scientific basis for supporting the use of cannabis is extensive, although it does not
necessarily translate into relevant clinical outcomes. The use of cannabinoids in acute pain …

The potential synergistic effects of combining cannabinoids and opioids for analgesia has
received considerable attention. No studies to date have evaluated this combination in …