The tumor microenvironment (TME) is composed of various cell types embedded in an
altered extracellular matrix (ECM). ECM not only serves as a support for tumor cell but also …

New growth in the vascular network is important since the proliferation, as well as metastatic
spread, of cancer cells depends on an adequate supply of oxygen and nutrients and the …

The microvascular endothelial cell monolayer localized at the critical interface between the
blood and vessel wall has the vital functions of regulating tissue fluid balance and supplying …

Angiogenesis inhibitors for the treatment of cancer have now been approved by the Food
and Drug Administration in the United States, and in 28 other countries including China …

The first angiogenesis inhibitors for cancer have now been approved by the FDA in the US
and in 28 other countries, including China. The majority of these are monotherapies that …

Background Angiogenesis is the process of neovascularization from pre-existing
vasculature and is involved in various physiological and pathological processes. Inhibitors …

The collagen family of extracellular matrix proteins has played a fundamental role in the
evolution of multicellular animals. At the present, 28 triple helical proteins have been named …

Angiogenesis, the formation of new blood vessels, is required for many pathologic
processes, including invasive tumor growth as well as physiologic organ/tissue …

The biology of basement membrane proteoglycans extends far beyond the original notion of
anionic filters. These complex molecules have dual roles as structural constituents of …

Tumstatin and endostatin are two inhibitors of angiogenesis derived from precursor human
collagen molecules known as α3 chain of type IV collagen and α1 chain of type XVIII …