Structure-based drug design is becoming an essential tool for faster and more cost-efficient
lead discovery relative to the traditional method. Genomic, proteomic, and structural studies …

Stroke induces a plastic state in the brain. This period of enhanced plasticity leads to the
sprouting of new axons, the formation of new synapses and the remapping of sensory-motor …

Antiretroviral therapy has changed human immunodeficiency virus (HIV) infection from a
near-certainly fatal illness to one that can be managed chronically. More patients are taking …

Extrinsic factors can adversely affect immune responses, producing states of secondary
immunodeficiency and consequent increased risk of infections. These immunodeficiencies …

Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease
that is caused by SARS coronavirus (SARS-CoV) and for which there are currently no …

Background We evaluated the efficacy of raltegravir and the development of viral resistance
in two identical trials involving patients who were infected with human immunodeficiency …

The pandemic evolution of SARS-CoV-2 infection is forcing the scientific community to
unprecedented efforts to explore all possible approaches against COVID-19. In this context …

To study virus–host protein interactions, knowledge about viral and host protein
architectures and repertoires, their particular evolutionary mechanisms, and information on …

HIV-1 eradication from infected individuals has not been achieved with the prolonged use of
highly active antiretroviral therapy (HAART). The cellular reservoir for HIV-1 in resting …

Psoriasis is a common immune-mediated chronic inflammatory skin disorder, but the
mechanisms of pathogenesis are still poorly understood. IL-23 is expressed in psoriatic skin …