Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …

Cognitive deficits associated with Alzheimer's disease (AD) severely impact daily life for the
millions of affected individuals. Progressive memory impairment in AD patients is associated …

Major depressive disorder (MDD) is a common emotional cognitive disorder that seriously
affects people's physical and mental health and their quality of life. Due to its clinical and …

Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

Mice lacking a microbiota are protected from diet-induced obesity. Previous studies have
shown that feeding a Western diet causes hypothalamic inflammation, which in turn can lead …

High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

Alzheimer's disease is the leading cause of dementia. Its increased prevalence in
developed countries, due to the sharp rise in ageing populations, presents one of the …

A theoretical framework is proposed to gain insight into the pathogenesis of major
depressive disorder (MDD). Despite being a relatively weak argument, the neurogenesis …

Numerous studies have shown that over-nutritional obesity may lead to pre-diabetes, type 2
diabetes and cognitive decline. As the degree of metabolic disorders increases, the …

Radial glia-like neural stem cells (RGLs) in the dentate gyrus subregion of the hippocampus
give rise to dentate granule cells (DGCs) and astrocytes throughout life, a process referred …