B Cell–Directed Therapy in Autoimmunity

I Abeles, C Palma, N Meednu, AS Payne… - Annual Review of …, 2024 - annualreviews.org
Autoimmune diseases with B cell–directed therapeutics approved by the US Food and Drug
Administration are surprisingly diverse in clinical manifestations and pathophysiology. In this …

Chimeric antigen receptor T-cell therapy in autoimmune diseases

J Liu, Y Zhao, H Zhao - Frontiers in Immunology, 2024 - frontiersin.org
The administration of T cells that have been modified to carry chimeric antigen receptors
(CARs) aimed at B cells has been an effective strategy in treating B cell malignancies. This …

The advent of chimeric antigen receptor T Cell therapy in recalibrating immune balance for rheumatic autoimmune disease treatment

Q Guo, J Li, J Wang, L Li, J Wei, L Zhang - Frontiers in Pharmacology, 2024 - frontiersin.org
CAR-T cell therapy, a cutting-edge cellular immunotherapy with demonstrated efficacy in
treating hematologic malignancies, also exhibits significant promise for addressing …

The lung as a target and as an initiator of rheumatoid arthritis-associated immunity: Implications for interstitial lung disease

ML Haarhaus, L Klareskog - Revista Colombiana de Reumatología …, 2024 - Elsevier
Interstitial lung disease (ILD) is a serious extra-articular co-morbidity in rheumatoid arthritis
(RA) patients and accounts for a substantial part of the increased mortality in RA. In this …