Farnesoid X receptor (FXR), a metabolic nuclear receptor, plays critical roles in the
maintenance of systemic energy homeostasis and the integrity of many organs, including …

The Farnesoid-X Receptor, FXR, is a nuclear bile acid receptor. Its originally described
function is in bile acid synthesis and regulation within the liver. More recently, however, FXR …

Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but
have also a key role as signaling molecules and in the modulation of epithelial cell …

Farnesoid X receptor (FXR, encoded by NR1H4), a critical regulator of bile acid
homeostasis, is widely implicated in human tumorigenesis. However, the functional role of …

Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell.
One of those alterations associated with cancer corresponds to differential expression of …

Bile acids (BAs) are known facilitators of nutrient absorption but recent paradigm shifts now
recognize BAs as signaling molecules regulating both innate and adaptive immunity. Bile …

Purpose: Metabolomics is a discovery tool for novel associations of metabolites with
disease. Here, we interrogated the metabolome of human breast tumors to describe …

Dietary factors, probiotic agents, aging and antibiotics/medicines impact on gut microbiome
composition leading to disturbances in localised microbial populations. The impact can be …

Colorectal cancer (CRC) stands as one of the most prevalent form of cancer globally,
causing a significant number of deaths, surpassing 0.9 million in the year 2020. According to …

The role of farnesoid X receptor (FXR) in cervical cancer and the underlying molecular
mechanism remain largely unknown. Therefore, this study aimed to assess the mechanism …