DHA/EPA (Omega-3) and LA/GLA (Omega-6) as bioactive molecules in neurodegenerative diseases

C Kousparou, M Fyrilla, A Stephanou… - International Journal of …, 2023 - mdpi.com
Neurodegenerative diseases are characterized by neuroinflammation, neuronal depletion
and oxidative stress. They coincide with subtle chronic or flaring inflammation, sometimes …

Structured long-chain omega-3 fatty acids for improvement of cognitive function during aging

I Mora, L Arola, A Caimari, X Escoté… - International journal of …, 2022 - mdpi.com
Although the human lifespan has increased in the past century owing to advances in
medicine and lifestyle, the human healthspan has not kept up the same pace, especially in …

Marine fish-derived lysophosphatidylcholine: Properties, extraction, quantification, and brain health application

MK Ahmmed, M Hachem, F Ahmmed, A Rashidinejad… - Molecules, 2023 - mdpi.com
Long-chain omega-3 fatty acids esterified in lysophosphatidylcholine (LPC-omega-3) are
the most bioavailable omega-3 fatty acid form and are considered important for brain health …

Emerging role of phospholipids and lysophospholipids for improving brain docosahexaenoic acid as potential preventive and therapeutic strategies for neurological …

M Hachem, H Nacir - International Journal of Molecular Sciences, 2022 - mdpi.com
Docosahexaenoic acid (DHA, 22: 6n-3) is an omega-3 polyunsaturated fatty acid (PUFA)
essential for neural development, learning, and vision. Although DHA can be provided to …

Brain targeting with docosahexaenoic acid as a prospective therapy for neurodegenerative diseases and its passage across blood brain barrier

M Hachem, M Belkouch, AL Van, M Picq… - Biochimie, 2020 - Elsevier
Abstract Docosahexaenoic acid (DHA, 22: 6n-3) is the main omega-3 polyunsaturated fatty
acid in brain tissues necessary for common brain growth and function. DHA can be provided …

Esterification of Docosahexaenoic Acid Enhances Its Transport to the Brain and Its Potential Therapeutic Use in Brain Diseases

A Lo Van, N Bernoud-Hubac, M Lagarde - Nutrients, 2022 - mdpi.com
Docosahexaenoic acid-containing lysophosphatidylcholine (DHA-LysoPC) is presented as
the main transporter of DHA from blood plasma to the brain. This is related to the major …

The Ω-3 fatty acid docosahexaenoic acid selectively induces apoptosis in tumor-derived cells and suppress tumor growth in gastric cancer

L Ortega, L Lobos-González, M Reyna-Jeldes… - European journal of …, 2021 - Elsevier
Despite current achievements and innovations in cancer treatment, conventional
chemotherapy has several limitations, such as unsatisfactory long-term survival, cancer drug …

Phospholipidomics in Clinical Trials for Brain Disorders: Advancing our Understanding and Therapeutic Potentials

M Hachem, MK Ahmmed, H Nacir-Delord - Molecular Neurobiology, 2024 - Springer
Phospholipidomics is a specialized branch of lipidomics that focuses on the characterization
and quantification of phospholipids. By using sensitive analytical techniques …

Progress & prospect of enzyme-mediated structured phospholipids preparation

Y Li, L Dai, D Liu, W Du - Catalysts, 2022 - mdpi.com
In recent years, structured phospholipids (SPLs), which are modified phospholipids (PLs),
have attracted more attention due to their great potential for application in the field of …

In vivo digestion of egg products enriched with DHA: Effect of the food matrix on DHA bioavailability

C Pineda-Vadillo, F Nau, C Guérin-Dubiard, C Bourlieu… - Foods, 2020 - mdpi.com
The aim of the present study was to determine to what extent the food matrix could affect the
release of docosahexaenoic acid (DHA) during digestion and its incorporation into systemic …