Immune checkpoint inhibitors combined with targeted therapy: the recent advances and future potentials

B Li, J Jin, D Guo, Z Tao, X Hu - Cancers, 2023 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) are the most mature treatment of
immunotherapy and have changed the mode of cancer treatment. Recent studies showed …

[HTML][HTML] Immunotherapy in glioblastoma treatment: Current state and future prospects

SLR Pinheiro, FFB Lemos, HS Marques… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Glioblastoma remains as the most common and aggressive malignant brain tumor, standing
with a poor prognosis and treatment prospective. Despite the aggressive standard care …

[HTML][HTML] Blood biomarkers predict outcomes in patients with hepatocellular carcinoma treated with immune checkpoint Inhibitors: A pooled analysis of 44 retrospective …

L Zhang, J Feng, T Kuang, D Chai, Z Qiu… - International …, 2023 - Elsevier
Objective We conducted the first meta-analysis to identify the predictive significance of
baseline blood biomarkers (such as neutrophil to lymphocyte ratio (NLR), early alpha …

Effectiveness and safety of atezolizumab-bevacizumab in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis

AV Kulkarni, H Tevethia, K Kumar, M Premkumar… - …, 2023 - thelancet.com
Background Atezolizumab-bevacizumab (atezo-bev) is recommended as first-line therapy
for patients with unresectable hepatocellular carcinoma (uHCC). However, its effectiveness …

Hypertransaminasemia in cancer patients receiving immunotherapy and immune-based combinations: the MOUSEION-05 study

A Rizzo, V Mollica, V Tateo, E Tassinari… - Cancer Immunology …, 2023 - Springer
Background The antitumor efficacy of immune checkpoint inhibitors (ICIs) has increasingly
emerged during the last few years. However, there is a need to identify the safety profile of …

Intermediate endpoints as surrogates for outcomes in cancer immunotherapy: a systematic review and meta-analysis of phase 3 trials

Z Zhang, Q Pan, M Lu, B Zhao - EClinicalMedicine, 2023 - thelancet.com
Background Cancer immunotherapy shows unique efficacy kinetics that differs from
conventional treatment. These characteristics may lead to the prolongation of trial duration …

B7x in cancer immunity and immunotherapy

K Mortezaee - International immunopharmacology, 2023 - Elsevier
B7x (also called B7-H4) is a co-inhibitory molecule of B7 family that is highly expressed in
non-inflamed or cold cancers, and its aberrant expression is contributed to cancer …

Doxorubicin-loaded platelet decoys for enhanced chemoimmunotherapy against triple-negative breast cancer in mice model

H Dong, M Gao, L Lu, R Gui, Y Fu - International Journal of …, 2023 - Taylor & Francis
Introduction Triple-negative breast cancer (TNBC) is a highly aggressive subtype with a poor
prognosis. Current single-agent checkpoint therapy has limited effectiveness in TNBC …

Predictive biomarkers for immune-checkpoint inhibitor treatment response in patients with hepatocellular carcinoma

JH Ji, SY Ha, D Lee, K Sankar, EK Koltsova… - International Journal of …, 2023 - mdpi.com
Hepatocellular carcinoma (HCC) has one of the highest mortality rates among solid cancers.
Late diagnosis and a lack of efficacious treatment options contribute to the dismal prognosis …

Efficacy and safety of apatinib combined with dose‐dense paclitaxel and carboplatin in neoadjuvant therapy for locally advanced triple‐negative breast cancer: A …

J Liu, M He, K Ou, X Wang, Y Wang, L Qi… - … Journal of Cancer, 2024 - Wiley Online Library
Optimizing neoadjuvant therapy for triple‐negative breast cancer (TNBC) is still an urgent
problem to be solved in the clinic. In this prospective cohort study, we investigated the …