The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Upon blood vessel injury, platelets are exposed to adhesive proteins in the vascular wall
and soluble agonists, which initiate platelet activation, leading to formation of hemostatic …

Thrombosis and inflammation are intricately linked in several major clinical disorders,
including disseminated intravascular coagulation and acute ischemic events. The damage …

Upon vascular injury, platelets are activated by adhesion to adhesive proteins, such as von
Willebrand factor and collagen, or by soluble platelet agonists, such as ADP, thrombin, and …

Molecular mimicry between viral antigens and host proteins can produce cross-reacting
antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a …

Platelet adhesion is an essential function in response to vascular injury and is generally
viewed as the first step during which single platelets bind through specific membrane …

Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric
oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been …

Hemostasis and pathological thrombus formation are dynamic processes that require
multiple adhesive receptor-ligand interactions, with blood platelets at the heart of such …

Endothelial prostacyclin and nitric oxide potently inhibit platelet functions. Prostacyclin and
nitric oxide actions are mediated by platelet adenylyl and guanylyl cyclases, which …

Bacterial LPS induces rapid thrombocytopenia, hypotension, and sepsis. Although growing
evidence suggests that platelet activation plays a critical role in LPS-induced …