Solid-state NMR: Methods for biological solids

S Ahlawat, KR Mote, NA Lakomek… - Chemical Reviews, 2022 - ACS Publications
In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

CSI 3.0: a web server for identifying secondary and super-secondary structure in proteins using NMR chemical shifts

NE Hafsa, D Arndt, DS Wishart - Nucleic acids research, 2015 - academic.oup.com
Abstract The Chemical Shift Index or CSI 3.0 (http://csi3. wishartlab. com) is a web server
designed to accurately identify the location of secondary and super-secondary structures in …

Unraveling the meaning of chemical shifts in protein NMR

MV Berjanskii, DS Wishart - Biochimica et Biophysica Acta (BBA)-Proteins …, 2017 - Elsevier
Chemical shifts are among the most informative parameters in protein NMR. They provide
wealth of information about protein secondary and tertiary structure, protein flexibility, and …

Local unfolding of the HSP27 monomer regulates chaperone activity

TR Alderson, J Roche, HY Gastall, DM Dias… - Nature …, 2019 - nature.com
The small heat-shock protein HSP27 is a redox-sensitive molecular chaperone that is
expressed throughout the human body. Here, we describe redox-induced changes to the …

Recognition and coacervation of G-quadruplexes by a multifunctional disordered region in RECQ4 helicase

AC Papageorgiou, M Pospisilova, J Cibulka… - Nature …, 2023 - nature.com
Biomolecular polyelectrolyte complexes can be formed between oppositely charged
intrinsically disordered regions (IDRs) of proteins or between IDRs and nucleic acids. Highly …

The inherent dynamics and interaction sites of the SARS-CoV-2 nucleocapsid N-terminal region

JS Redzic, E Lee, A Born, A Issaian, MA Henen… - Journal of Molecular …, 2021 - Elsevier
The nucleocapsid protein is one of four structural proteins encoded by SARS-CoV-2 and
plays a central role in packaging viral RNA and manipulating the host cell machinery, yet its …

Quenching protein dynamics interferes with HIV capsid maturation

M Wang, CM Quinn, JR Perilla, H Zhang… - Nature …, 2017 - nature.com
Maturation of HIV-1 particles encompasses a complex morphological transformation of Gag
via an orchestrated series of proteolytic cleavage events. A longstanding question concerns …

The supramolecular organization of a peptide-based nanocarrier at high molecular detail

M Rad-Malekshahi, KM Visscher… - Journal of the …, 2015 - ACS Publications
Nanovesicles self-assembled from amphiphilic peptides are promising candidates for
applications in drug delivery. However, complete high-resolution data on the local and …

Structure and function of the silicifying peptide R5

L Senior, MP Crump, C Williams, PJ Booth… - Journal of Materials …, 2015 - pubs.rsc.org
The 19-mer synthetic peptide known as R5 has been used widely in studies of peptide-
driven silica condensation. Despite this, the structure and function of R5 have not yet been …

Mechanism-based inhibition of an aldolase at high concentrations of its natural substrate acetaldehyde: structural insights and protective strategies

M Dick, R Hartmann, OH Weiergräber, C Bisterfeld… - Chemical …, 2016 - pubs.rsc.org
2-Deoxy-D-ribose-5-phosphate aldolase (DERA) is used in organic synthesis for the
enantioselective reaction between acetaldehyde and a broad range of other aldehydes as …