The present invention is related to a ribonucleic acid com prising a double stranded
structure whereby the double Stranded structure comprises a first strand and a second …

Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are
provided that have subsequences of 2'-pentoribofuranosyl nucleosides that activate …

2004-05-18 Assigned to ISIS PHARMACEUTICALS, INC. reassignment ISIS
PHARMACEUTICALS, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT …

The present invention provides oligomeric compounds hav ing su? icient complementarity to
hybridize to a nucleic acid target and methods for their use in modulating gene expres sion …

The invention relates to improved RNAi constructs and uses thereof. The construct has a
double stranded region of 19-49 nucleotides, preferably 25, 26, or 27 nucleotides, and …

The present invention provides, inter alia, methods of Select ing a single-Stranded
oligomeric compounds for inhibiting RNA expression, methods of generating double …

2013-06-19 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

2013-01-11 Assigned to RXI PHARMACEUTICALS CORPORATION reassignment RXI
PHARMACEUTICALS CORPORATION ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

The present invention is related to a ribonucleic acid comprising a double stranded structure
whereby the double-stranded structure comprises a first strand and a second strand …

The present invention relates to RNAi constructs with minimal double-stranded regions, and
their use in gene silencing. RNAi constructs associated with the invention include a double …