Polyphenolic flavonoids are considered natural, non-toxic chemopreventers, which are most
commonly derived from plants, fruits, and vegetables. Most of these polyphenolics exhibit …

Patients with refractory or relapsed acute myeloid leukemia (R/R AML) have a poor
prognosis, with a high unmet medical need. Idasanutlin is a small-molecule inhibitor of …

Background Venetoclax (VEN) in combination with a hypomethylating agent (HMA) has
become the standard of care for patients aged> 75 years and for those not eligible for …

Loss of p53—a tumor suppressor gene located on the short arm of chromosome 17 (band
17p13. 1)—was detected in 105 out of 2272 (5%) adult acute myeloid leukemia (AML) …

The prognosis remains poor for patients with relapsed or refractory (r/r) acute myeloid
leukemia; thus, novel therapies are needed. We evaluated idasanutlin—a new, potent …

Oligonucleotide (ODN)-capped gold nanoparticles (Au–NPs) were used in a sandwich
assay of ODN or polynucleotide by a flow injection surface plasmon resonance (SPR). A …

The mechanism of the cytotoxic effect of boswellic acid acetate, a 1: 1 mixture of α-boswellic
acid acetate and β-boswellic acid acetate, isolated from Boswellia carterri Birdw on myeloid …

Acute promyelocytic leukemia (APL) is distinguished from other acute myeloid leukemias
(AMLs) by cytogenetic, clinical, as well as biological characteristics. The hallmark of APL is …

This study proposes to investigate quercetin antitumor efficacy in vitro and in vivo, using the
P39 cell line as a model. The experimental design comprised leukemic cells or xenografts of …

DNA damage exposure is a major modifier of cell fate in both normal and cancer tissues. In
response to DNA damage, myeloid leukemia cells activate a poorly understood terminal …