The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Fibrinogen and fibrin are essential for hemostasis and are major factors in thrombosis,
wound healing, and several other biological functions and pathological conditions. The X …

Living systems operate far from thermodynamic equilibrium. Enzymatic activity can induce
broken detailed balance at the molecular scale. This molecular scale breaking of detailed …

Animal cells in tissues are supported by biopolymer matrices, which typically exhibit highly
nonlinear mechanical properties. While the linear elasticity of the matrix can significantly …

The ability of cells to sense and respond to mechanical signals is vital in development and
healthy tissue functioning. Many diseases are related to either changing mechanical …

Tissue injury disrupts the mechanical homeostasis that underlies normal tissue architecture
and function. The failure to resolve injury and restore homeostasis gives rise to progressive …

Cells actively sense and process mechanical information that is provided by the extracellular
environment to make decisions about growth, motility and differentiation. It is important to …

Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …

Stem cells hold great promise for widespread biomedical applications, for which stem cell
fate needs to be well tailored. Besides biochemical cues, accumulating evidence has …

Fibrin is a protein polymer that is essential for hemostasis and thrombosis, wound healing,
and several other biological functions and pathological conditions that involve extracellular …