Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of hybrid natural products
sharing the mevalonate/methylerythritol phosphate and polyketide biosynthetic pathways …

First-row transition-metal-mediated reactions constitute an important and growing area of
research due to the low cost, low toxicity, and exceptional synthetic versatility of these …

Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …

We report the first total synthesis of hypersampsone M, an archetypal member of the
homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs). Commencing …

Covering: up to mid-2019 This review highlights the utilization of biomass-derived building
blocks in the total synthesis of natural products. An overview over several renewable …

Conspectus Natural products are biosynthesized from a limited pool of starting materials via
pathways that obey the same chemical logic as textbook organic reactions. Given the …

A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural
product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled …

Polycyclic polyprenylated acylphloroglucinols (PPAPs) are a class of> 400 natural products
with a broad spectrum of bioactivity, ranging from antidepressant and antimicrobial to anti …

Hypermonols A–E (1–5), which are highly modified nor-seco-polycyclic polyprenylated
acylphloroglucinols with an unprecedentedly linear 5-5/6/5 tetracyclic skeleton, were …

Capitalizing on the late‐stage diversification of an essential 1, 3‐diene intermediate, we
describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+) …