Poly-and perfluoroalkyl substances (PFAS) are manmade synthetic chemicals which have
been in existence for over 70 years. Though they are currently being phased out, their …

The Leydig cells of the testis have the capacity to biosynthesize testosterone from
cholesterol. Testosterone and its metabolically activated product dihydrotestosterone are …

STUDY QUESTION Is exposure to perfluorinated compounds (PFCs) associated with
testicular function (reproductive hormone levels and semen quality) in healthy men …

Per-fluoroalkyl and polyfluoroalkyl substances (PFAS) are a diverse group of synthetic
fluorinated chemicals used widely in industry and consumer products. Due to their extensive …

Placenta contains 3β-hydroxysteroid dehydrogenase/steroid Δ 5, 4-isomerase (HSD3B),
which catalyzes pregnenolone to progesterone for maintaining pregnancy. Perfluoroalkyl …

Steroid estrogens have been detected in oceans, rivers, lakes, groundwaters, soils, and
even urban water supply systems, thereby inevitably imposing serious impacts on human …

Background Few studies have explored the association between perfluoroalkyl substances
(PFAS) and reproductive hormones in adolescents and young adults. Objectives This study …

BACKGROUND Perfluorinated compounds (PFCs) have been suspected to adversely affect
human reproductive health. The aim of this study was to investigate the associations …

Background Exposure to perfluoroalkyl substances (PFASs) may disrupt reproductive
function in animals and humans. Although PFASs can cross the human placental barrier …

Perfluoroalkyl chemicals induce male reproductive toxicity. Current evidence showed the
effects of the chemical exposure on the deterioration of testicular functions, and reduction in …