Therapeutic targeting of trained immunity

WJM Mulder, J Ochando, LAB Joosten… - Nature reviews Drug …, 2019 - nature.com
Immunotherapy is revolutionizing the treatment of diseases in which dysregulated immune
responses have an important role. However, most of the immunotherapy strategies currently …

Nanodiscs: a versatile nanocarrier platform for cancer diagnosis and treatment

J Bariwal, H Ma, GA Altenberg, H Liang - Chemical Society Reviews, 2022 - pubs.rsc.org
Cancer therapy is a significant challenge due to insufficient drug delivery to the cancer cells
and non-selective killing of healthy cells by most chemotherapy agents. Nano-formulations …

Noninvasive imaging of nanomedicines and nanotheranostics: principles, progress, and prospects

S Kunjachan, J Ehling, G Storm, F Kiessling… - Chemical …, 2015 - ACS Publications
Nanomedicine is defined as “the application of nanotechnology to medicine, including the
use of nanometer-sized carrier materials for facilitating disease diagnosis, disease treatment …

Bionanoparticles in cancer imaging, diagnosis, and treatment

Y Li, Q Bao, S Yang, M Yang, C Mao - View, 2022 - Wiley Online Library
Biological molecules such as DNA, proteins, and lipids can be assembled into naturally
existing nanoparticles, such as bacterial viruses (also called bacteriophages or phages) …

High-density lipoproteins: nature's multifunctional nanoparticles

R Kuai, D Li, YE Chen, JJ Moon, A Schwendeman - ACS nano, 2016 - ACS Publications
High-density lipoproteins (HDL) are endogenous nanoparticles involved in the transport and
metabolism of cholesterol, phospholipids, and triglycerides. HDL is well-known as the …

Passive versus active tumor targeting using RGD-and NGR-modified polymeric nanomedicines

S Kunjachan, R Pola, F Gremse, B Theek, J Ehling… - Nano …, 2014 - ACS Publications
Enhanced permeability and retention (EPR) and the (over-) expression of angiogenesis-
related surface receptors are key features of tumor blood vessels. As a consequence, EPR …

Lipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis

JL Huang, G Jiang, QX Song, X Gu, M Hu… - Nature …, 2017 - nature.com
Hyperactivated Ras regulates many oncogenic pathways in several malignant human
cancers including glioblastoma and it is an attractive target for cancer therapies. Ras …

Peptide-based nanoprobes for molecular imaging and disease diagnostics

P Zhang, Y Cui, CF Anderson, C Zhang, Y Li… - Chemical Society …, 2018 - pubs.rsc.org
Pathological changes in a diseased site are often accompanied by abnormal activities of
various biomolecules in and around the involved cells. Identifying the location and …

Lipoproteins and lipoprotein mimetics for imaging and drug delivery

CS Thaxton, JS Rink, PC Naha, DP Cormode - Advanced drug delivery …, 2016 - Elsevier
Lipoproteins are a set of natural nanoparticles whose main role is the transport of fats within
the body. While much work has been done to develop synthetic nanocarriers to deliver …

In vivo assembly of nanoparticle components to improve targeted cancer imaging

SD Perrault, WCW Chan - Proceedings of the National …, 2010 - National Acad Sciences
Many small molecular anticancer agents are often ineffective at detecting or treating cancer
due to their poor pharmacokinetics. Using nanoparticles as carriers can improve this …