Highlights•mAbs mixture targeting independent epitopes are better therapeutics.•Optimizing
antibody efficacy: in vitro maturation, afucosylation, Fc modifications.•Monitoring of natural …

Viruses in the family Filoviridae, including the commonly known Ebola (EBOV) and Marburg
(MARV) viruses, can cause severe hemorrhagic fever in humans and nonhuman primates …

Several ebolaviruses cause outbreaks of severe disease. Vaccines and monoclonal
antibody cocktails are available to treat Ebola virus (EBOV) infections, but not Sudan virus …

Rodent-borne hantaviruses are prevalent worldwide and upon spillover to human
populations, cause severe disease for which no specific treatment is available. A potent …

Hantaviruses are high-priority emerging pathogens carried by rodents and transmitted to
humans by aerosolized excreta or, in rare cases, person-to-person contact. While infections …

Due to its high mortality rate and continued re-emergence, Ebolavirus disease (EVD)
continues to pose a serious threat to global health. A group of viruses within the genus …

Filoviruses, including ebolaviruses and marburgviruses, can cause severe and often fatal
disease in humans. Over the past several years, antibody therapy has emerged as a …

The eradication of smallpox was officially declared by the WHO in 1980, leading to
discontinuation of the vaccination campaign against the virus. Consequently, immunity …

Real-time cell analysis (RTCA) enables high-throughput, quantitative kinetic measurements
of cytopathic effect (CPE) in virus-infected cells. Here, we detail a RTCA approach for …

The filoviruses, including ebolaviruses and marburgviruses, are among the world's deadliest
pathogens. As the only surface-exposed protein on mature virions, their glycoprotein GP is …