A better understanding of the pathophysiology of rheumatoid arthritis, together with
influential trials aimed at treating early stages of the disease, has altered therapy. This article …

Background Glucocorticoid use in rheumatoid arthritis (RA) is widespread. Two Cochrane
Reviews have been published examining the short term clinical benefit of low dose …

Objective: To formulate EULAR recommendations for the management of early arthritis.
Methods: In accordance with EULAR's “standardised operating procedures”, the task force …

Background Phase II trials of leflunomide, an inhibitor of de-novo pyrimidine synthesis, have
shown efficacy in rheumatoid arthritis. This double-blind randomised trial compared …

Objectives. To assess the proportion of RA patients who discontinued biologics in world
registries and health care databases and to identify causes and predictors of …

Methotrexate (MTX) is now the most popular drug worldwide for the treatment of rheumatoid
arthritis. Low-dose, weekly MTX (10 to 25 mg/wk) used as either monotherapy or in …

Objective. To compare the clinical efficacy and safety of leflunomide and methotrexate for
the treatment of rheumatoid arthritis (RA). Methods. In this multicentre, double‐blind trial …

Periodontitis and rheumatoid arthritis (RA) appear to share many pathologic features. In this
review, the common pathologic mechanisms of these two common chronic conditions are …

A systematic review of the effectiveness of adalimumab, etanercept and infliximab for the
treatment of rheumatoid arthritis in adults and an economic evaluation of their cost-effectiveness …

The two major advances over the 1990s in the treatment of rheumatoid arthritis (RA) were a
shift in strategy from a" pyramid", in which disease modifying anti-rheumatic drugs …