The development of interventions to slow or halt the progression of Parkinson's disease
remains a priority for patients and researchers alike. To date, no agents have been shown to …

Oxidative stress plays an important role in the degeneration of dopaminergic neurons in
Parkinson's disease (PD). Disruptions in the physiologic maintenance of the redox potential …

Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …

Oxidative stress including DNA damage, increased lipid and protein oxidation, are important
features of aging and neurodegeneration suggesting that endogenous antioxidant protective …

Background Identifying factors influencing phenotypic heterogeneity in Parkinson's Disease
is crucial for understanding variability in disease severity and progression. Age and gender …

Many agents developed for neuroprotective treatment of Parkinson disease (PD) have
shown great promise in the laboratory, but none have translated to positive results in …

Background: Studies suggest that dihydropyridine calcium-channel blockers may be
associated with reduced risk for Parkinson disease (PD). Objective: To assess the effect of …

Background: Identifying a meaningful progression metric for Parkinson's disease (PD) that
reflects heterogeneity remains a challenge. Objective: To assess the frequency and baseline …

Importance Convergent biological, epidemiological, and clinical data identified urate
elevation as a candidate strategy for slowing disability progression in Parkinson disease …

Parkinson disease is an inexorably progressive neurodegenerative disorder. Multiple
attempts have been made to establish therapies for Parkinson disease which provide …