Bioconjugation methodologies have proven to play a central enabling role in the recent
development of biotherapeutics and chemical biology approaches. Recent endeavours in …

Bispecific antibodies (bsAbs) target two different epitopes. These are an up-and-coming
class of biologics, with two such therapeutics (emicizumab and blinatumomab) FDA …

A new and versatile class of cyclic diazodicarboxamides that reacts efficiently and
selectively with phenols and the phenolic side chain of tyrosine through an ene-like reaction …

The scope, chemoselectivity, and utility of the click-like tyrosine labeling reaction with 4-
phenyl-3 H-1, 2, 4-triazoline-3, 5 (4 H)-diones (PTADs) is reported. To study the utility and …

Bispecific antibodies were constructed using genetically encoded unnatural amino acids
with orthogonal chemical reactivity. A two-step process afforded homogeneous products in …

Synthetic immunology, the development of synthetic systems capable of modulating and/or
manipulating immunological functions, represents an emerging field of research with …

Bispecific antibodies (BsAbs) are regarded as promising therapeutic agents due to their
ability to simultaneously bind two different antigens. Several bispecific modalities have been …

Current routes for synthesizing antibody–drug conjugates commonly rely on maleimide
linkers to react with cysteine thiols. However, thioether exchange with metabolites and …

The review outlines progress and problems in the design of non-natural antibodies for
clinical applications over the past $10 {-} 15\{\text {years}} $. The modular structure of natural …

Monoclonal antibodies are traditionally used to block the function of a specific target in a
given disease. However, some diseases are the consequence of multiple components or …