The definition and classification of chronic kidney disease (CKD) have evolved over time,
but current international guidelines define this condition as decreased kidney function …

Phenolic compounds are a group of metabolites derived from the secondary pathways of
plants. Polyphenols comprise flavonoids, phenolic acids, tannins, lignans, and coumarins …

Rhein is an anthraquinone compound isolated from the medicinal plant rhubarb and mainly
used in the clinical treatment of diabetic nephropathy. Rhein exhibits various renoprotective …

Renal fibrosis is an unavoidable end result of all forms of progressive chronic kidney
diseases (CKD). Discovery of efficacious drugs against renal fibrosis is in crucial need. In a …

In chronic kidney disease (CKD), proteinuria results in severe tubulointerstitial lesions,
which ultimately lead to end-stage renal disease. Here we identify 4-phenylbutyric acid …

Background Chronic kidney disease (CKD) is characterized as a progressive dysfunction of
the kidney, and it might have a close relationship with insulin resistance. We utilized the …

Chronic kidney disease (CKD) is increasingly being accepted as a type of renal ageing. The
kidney undergoes age-related alterations in both structure and function. To date, a …

Renal fibrosis is a common pathological feature of chronic kidney diseases (CKD) and its
development and progression are significantly affected by epigenetic modifications such as …

Background Chronic kidney disease (CKD) is defined by abnormalities in kidney structure
and/or function present for more than 3 months. Worldwide, both the incidence and …

Background A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to
developing diabetic kidney disease (DKD), the most common cause globally of end-stage …