Spheroids-on-a-chip: Recent advances and design considerations in microfluidic platforms for spheroid formation and culture
A cell spheroid is a three-dimensional (3D) aggregation of cells. Synthetic, in-vitro spheroids
provide similar metabolism, proliferation, and species concentration gradients to those found …
provide similar metabolism, proliferation, and species concentration gradients to those found …
Breast cancer models: Engineering the tumor microenvironment
The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …
development of clinically relevant models to study cancer biology and drug response in …
Targeting hypoxia: hypoxia-activated prodrugs in cancer therapy
Y Li, L Zhao, XF Li - Frontiers in Oncology, 2021 - frontiersin.org
Hypoxia is an important characteristic of most solid malignancies, and is closely related to
tumor prognosis and therapeutic resistance. Hypoxia is one of the most important factors …
tumor prognosis and therapeutic resistance. Hypoxia is one of the most important factors …
Cell‐inspired all‐aqueous microfluidics: from intracellular liquid–liquid phase separation toward advanced biomaterials
Living cells have evolved over billions of years to develop structural and functional
complexity with numerous intracellular compartments that are formed due to liquid–liquid …
complexity with numerous intracellular compartments that are formed due to liquid–liquid …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment
Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …
disease. To overcome the major challenges in cancer therapy, we need to have a better …
Biomaterials‐based approaches to tumor spheroid and organoid modeling
Evolving understanding of structural and biological complexity of tumors has stimulated
development of physiologically relevant tumor models for cancer research and drug …
development of physiologically relevant tumor models for cancer research and drug …
Optical clearing methods: an overview of the techniques used for the imaging of 3D spheroids
EC Costa, DN Silva, AF Moreira… - Biotechnology and …, 2019 - Wiley Online Library
Spheroids have emerged as in vitro models that reproduce in a great extent the architectural
microenvironment found in human tissues. However, the imaging of 3D cell cultures is highly …
microenvironment found in human tissues. However, the imaging of 3D cell cultures is highly …
Advanced biomaterials and microengineering technologies to recapitulate the stepwise process of cancer metastasis
Cancer is one of the leading causes of death globally according to the World Health
Organization. Although improved treatments and early diagnoses have reduced cancer …
Organization. Although improved treatments and early diagnoses have reduced cancer …
The hypoxia-activated prodrug TH-302: exploiting hypoxia in cancer therapy
Y Li, L Zhao, XF Li - Frontiers in pharmacology, 2021 - frontiersin.org
Hypoxia is an important feature of most solid tumors, conferring resistance to radiation and
many forms of chemotherapy. However, it is possible to exploit the presence of tumor …
many forms of chemotherapy. However, it is possible to exploit the presence of tumor …