With extremely short generation times and high mutability, many viruses can rapidly evolve
and adapt to changing environments. This ability is generally beneficial to viruses as it …

Viral latency is a major barrier to curing HIV infection with antiretroviral therapy, and
consequently, for eliminating the disease globally. The establishment, maintenance, and …

Within-host HIV populations continually diversify during untreated infection, and this diversity
persists within infected cell reservoirs during antiretroviral therapy (ART). Achieving a better …

A clinical trial was performed to evaluate 3BNC117, a potent anti–HIV-1 antibody, in infected
individuals during suppressive antiretroviral therapy and subsequent analytical treatment …

Phylogenetic inference is an attractive means to reconstruct transmission histories and
epidemics. However, there is not a perfect correspondence between transmission history …

HIV-1 undergoes multiple rounds of error-prone replication between transmission events,
resulting in diverse viral populations within and among individuals. In addition, the virus …

The existence of long-lived reservoirs of latently infected CD4+ T cells is the major barrier to
curing HIV, and has been extensively studied in this light. However, the effect of these …

Currently, HIV-1 displays a substantial level of genetic diversity on a global scale, partly
attributed to its recombinant variants. This study seeks to identify and analyze HIV-1 …

Type I interferons, particularly interferon-alpha (IFN-α), play a vital role in the host's anti-viral
defenses by interfering with viral replication. However, the virus rapidly evolves to exploit the …

The evolution of HIV-1 in a host is shaped by many evolutionary forces, including
recombination of virus genomes and the potential isolation of viruses into different tissues …