Many diseases are caused by insufficient expression of mutated genes and would benefit
from increased expression of the corresponding protein. However, in drug development, it …

MicroRNAs (miRNAs) play indispensable roles in posttranscriptional gene regulation. Their
cellular regulatory impact is determined not solely by their sheer number, which likely …

During the COVID-19 pandemic, Pfizer-BioNTech and Moderna successfully developed
nucleoside-modified mRNA lipid nanoparticle (LNP) vaccines. SARS-CoV-2 spike protein …

Multidrug resistance (MDR) is one of the primary factors that produces treatment failure in
patients receiving cancer chemotherapy. MDR is a complex multifactorial phenomenon …

The majority of human mRNAs generate alternative 3′ untranslated regions (UTRs)
through various processes, including RNA modifications such as RNA editing, m 6 A …

As it is well known, messenger RNA has many regulatory regions along its sequence length.
One of them is the 5′ untranslated region (5'UTR), which itself contains many regulatory …

Background Coronary heart disease (CHD) is the leading cause of death in the world.
Unfortunately, many of the key diagnostic tools for CHD are insensitive, invasive, and costly; …

Competing endogenous RNAs (ceRNAs) are transcripts that possess highly similar
microRNA response elements (MREs). microRNAs (miRNAs) are short, endogenous, single …

The biology of preimplantation embryo gene expression began 56 years ago with studies of
the effects of protein synthesis inhibition and discovery of changes in embryo metabolism …

Disturbances in lipid metabolism related to excessive food intake and sedentary lifestyle are
among major risk of various metabolic disorders. Stearoyl-CoA desaturase-1 (SCD1) has an …