Natural products (NPs) have played a key role in drug discovery and are still a prolific
source of novel lead compounds or pharmacophores for medicinal chemistry …

Berberine (BBR) is a multi-target drug (MTD) that has proven effective in the treatment of
metabolism-related chronic diseases (CDs). However, the mode of action (MOA) of BBR …

Heart aging is characterized by left ventricular hypertrophy and diastolic dysfunction, which
in turn induces a variety of cardiovascular diseases. There is still no therapeutic drug to …

Berberine (1) is an alkaloid used widely in the treatment of several diseases. However, its
physicochemical properties, pharmacokinetics, and metabolism remain unclear, and …

A series of novel berberine-benzimidazole derivatives were conveniently and efficiently
synthesized and characterized by NMR, IR, MS and HRMS spectra. Most of the prepared …

Ulcerative colitis (UC) is a chronic relapsing disease without satisfactory treatments, in which
intestinal inflammation and disrupted intestinal epithelial barrier are two main pathogeneses …

Introduction Berberine (BBR), as one of the outstanding representatives of isoquinoline
alkaloids, has been used as an antibacterial drug for a long time in China since ancient …

Background Berberine (BBR) is a drug with multiple effects on cellular energy metabolism.
The present study explored answers to the question of which CYP450 (Cytochrome P450) …

Background: Berberine (BBR), a natural product, was reported to inhibit platelet
aggregation; however, the molecular mechanisms remain unclear. This study aims to …

Berberine, as a representative isoquinoline alkaloid, exhibits significant hypolipidemic
activity in both animal models and clinical trials. Recently, a large number of studies on the …