Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …

Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …

Epigenetics is one of the most promising and expanding fields in the current biomedical
research landscape. Since the inception of epigenetics in the 1940s, the discoveries …

Gene transcription can be activated or inhibited by a reversible modification of the gene; this
modification is termed an epigenetic change. This account of epigenetics in cancer reviews …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

An altered pattern of epigenetic modifications is central to many common human diseases,
including cancer. Many studies have explored the mosaic patterns of DNA methylation and …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

The development of more specific biomarkers for prostate cancer and/or high‐risk prostate
cancer is necessary, because the prostate‐specific antigen test lacks specificity for the …