Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

Cancer comprises a group of heterogeneous diseases encompassing high rates of
morbidity and mortality. Heterogeneity, which is a hallmark of cancer, is one of the main …

Accumulating evidence suggests that cancer-associated mesenchymal stem cells (MSC)
contribute to the development and metastasis of hepatocellular carcinoma (HCC). Aberrant …

The histone H3K36 methyltransferase SETD2 is frequently mutated or deleted in a variety of
human tumors. Nevertheless, the role of SETD2 loss in oncogenesis remains largely …

Abstract Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to
collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts …

The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

Abstract β-catenin is the key transducer of the canonical Wnt signaling. Aberrant activation of
β-catenin has been tightly connected to the initiation and progression of various cancers …

The intestinal stem cell (ISC) marker LGR5 is a receptor for R‐spondin (RSPO) that functions
to potentiate Wnt signalling in the proliferating crypt. It has been recently shown that Wnt …

ABSTRACT β-catenin is an evolutionary conserved, quintessential, multifaceted protein that
plays vital roles in cellular homeostasis, embryonic development, organogenesis, stem cell …

Abstract Background Wingless and Int-related protein (Wnt) ligands are aberrantly
expressed in patients with colorectal cancer (CRC). However, the aberrant level of Wnt …