CaMKII as a therapeutic target in cardiovascular disease
OE Reyes Gaido, LJ Nkashama… - Annual review of …, 2023 - annualreviews.org
CaMKII (the multifunctional Ca2+ and calmodulin-dependent protein kinase II) is a highly
validated signal for promoting a variety of common diseases, particularly in the …
validated signal for promoting a variety of common diseases, particularly in the …
Astrocytes regulate inhibitory neurotransmission through GABA uptake, metabolism, and recycling
JV Andersen, A Schousboe… - Essays in …, 2023 - portlandpress.com
Synaptic regulation of the primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) is
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …
essential for brain function. Cerebral GABA homeostasis is tightly regulated through multiple …
CaMKII autophosphorylation can occur between holoenzymes without subunit exchange
The dodecameric protein kinase CaMKII is expressed throughout the body. The alpha
isoform is responsible for synaptic plasticity and participates in memory through its …
isoform is responsible for synaptic plasticity and participates in memory through its …
New Psychoactive Substances: Major Groups, Laboratory Testing Challenges, Public Health Concerns, and Community‐Based Solutions
Across communities worldwide, various new psychoactive substances (NPSs) continue to
emerge, which worsens the challenges to global mental health, drug rules, and public health …
emerge, which worsens the challenges to global mental health, drug rules, and public health …
Polymer-based microfluidic device for on-chip counter-diffusive crystallization and in situ X-ray crystallography at room temperature
Proteins are long chains of amino acid residues that perform a myriad of functions in living
organisms, including enzymatic reactions, signalling, and maintaining structural integrity …
organisms, including enzymatic reactions, signalling, and maintaining structural integrity …
Role of Ca2+/Calmodulin-Dependent Protein Kinase Type II in Mediating Function and Dysfunction at Glutamatergic Synapses
AG Mohanan, S Gunasekaran, RS Jacob… - Frontiers in molecular …, 2022 - frontiersin.org
Glutamatergic synapses harbor abundant amounts of the multifunctional Ca2+/calmodulin-
dependent protein kinase type II (CaMKII). Both in the postsynaptic density as well as in the …
dependent protein kinase type II (CaMKII). Both in the postsynaptic density as well as in the …
Hub stability in the calcium calmodulin-dependent protein kinase II
The calcium calmodulin protein kinase II (CaMKII) is a multi-subunit ring assembly with a
central hub formed by the association domains. There is evidence for hub polymorphism …
central hub formed by the association domains. There is evidence for hub polymorphism …
How hypocretin agonists may improve the quality of wake in narcolepsy
Excessive daytime sleepiness (EDS) is a complex symptom characterized by a strong urge
to sleep during daytime accompanied by problems such as attention deficits, anxiety, and …
to sleep during daytime accompanied by problems such as attention deficits, anxiety, and …
The GHB analogue HOCPCA improves deficits in cognition and sensorimotor function after MCAO via CaMKIIα
N Griem-Krey, AB Klein, BH Clausen… - Journal of Cerebral …, 2023 - journals.sagepub.com
Ca2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a major contributor to
physiological and pathological glutamate-mediated Ca2+ signals, and its involvement in …
physiological and pathological glutamate-mediated Ca2+ signals, and its involvement in …
[HTML][HTML] The CaMKIIα hub ligand Ph-HTBA promotes neuroprotection after focal ischemic stroke by a distinct molecular interaction
N Griem-Krey, SJ Gauger, EK Gowing… - Biomedicine & …, 2022 - Elsevier
Abstract Ca 2+/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a potential target
for acute neuroprotection due to its key role in physiological and pathological glutamate …
for acute neuroprotection due to its key role in physiological and pathological glutamate …