TGF‐β signalling and liver disease

I Fabregat, J Moreno‐Càceres, A Sánchez… - The FEBS …, 2016 - Wiley Online Library
The transforming growth factor‐beta (TGF‐β) family signalling pathways play essential roles
in the regulation of different cellular processes, including proliferation, differentiation …

Expression and function of the epidermal growth factor receptor in physiology and disease

J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

Stem cell therapy in liver regeneration: Focus on mesenchymal stem cells and induced pluripotent stem cells

L Zhang, YY Fei, HT Han, J Xu, L Cheng, X Li - Pharmacology & …, 2022 - Elsevier
The liver has the ability to repair itself after injury; however, a variety of pathological changes
in the liver can affect its ability to regenerate, and this could lead to liver failure …

EGFR signaling in liver diseases

K Komposch, M Sibilia - International journal of molecular sciences, 2015 - mdpi.com
The epidermal growth factor receptor (EGFR) is a transmembrane receptor tyrosine kinase
that is activated by several ligands leading to the activation of diverse signaling pathways …

[PDF][PDF] Platelets: No longer bystanders in liver disease

A Chauhan, DH Adams, SP Watson, PF Lalor - Hepatology, 2016 - Wiley Online Library
Growing lines of evidence recognize that platelets play a central role in liver homeostasis
and pathobiology. Platelets have important roles at every stage during the continuum of liver …

[PDF][PDF] Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

N Goikoetxea‐Usandizaga, M Serrano‐Maciá… - …, 2022 - Wiley Online Library
Abstract Background and Aims Hepatic ischemia–reperfusion injury (IRI) is the leading
cause of early posttransplantation organ failure as mitochondrial respiration and ATP …

[PDF][PDF] Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver …

S Paranjpe, WC Bowen, WM Mars, A Orr… - …, 2016 - Wiley Online Library
Receptor tyrosine kinases MET and epidermal growth factor receptor (EGFR) are critically
involved in initiation of liver regeneration. Other cytokines and signaling molecules also …

[PDF][PDF] Angiopoietin‐like protein 1 antagonizes MET receptor activity to repress sorafenib resistance and cancer stemness in hepatocellular carcinoma

HA Chen, TC Kuo, CF Tseng, JT Ma, ST Yang… - …, 2016 - Wiley Online Library
Angiopoietin‐like protein 1 (ANGPTL1) has been shown to act as a tumor suppressor by
inhibiting angiogenesis, cancer invasion, and metastasis. However, little is known about the …

Lgr5+ pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis

CH Ang, SH Hsu, F Guo, CT Tan… - Proceedings of the …, 2019 - National Acad Sciences
Emerging evidence suggests that hepatocytes are primarily maintained by self-renewal
during normal liver homeostasis, as well as in response to a wide variety of hepatic injuries …

New and Old Key Players in Liver Cancer

ÁM Cuesta, N Palao, P Bragado… - International Journal of …, 2023 - mdpi.com
Liver cancer represents a major health problem worldwide with growing incidence and high
mortality, hepatocellular carcinoma (HCC) being the most frequent. Hepatocytes are likely …