Technological innovations in photochemistry for organic synthesis: flow chemistry, high-throughput experimentation, scale-up, and photoelectrochemistry

L Buglioni, F Raymenants, A Slattery… - Chemical …, 2021 - ACS Publications
Photoinduced chemical transformations have received in recent years a tremendous amount
of attention, providing a plethora of opportunities to synthetic organic chemists. However …

Recent applications of C–H functionalization in complex natural product synthesis

DJ Abrams, PA Provencher, EJ Sorensen - Chemical Society Reviews, 2018 - pubs.rsc.org
In this review, recent examples featuring C–H functionalization in the synthesis of complex
natural products are discussed. A focus is given to the way in which C–H functionalization …

Strategies and lessons learned from total synthesis of taxol

L Min, JC Han, W Zhang, CC Gu, YP Zou… - Chemical …, 2023 - ACS Publications
Taxol (paclitaxel), the most well-known taxane diterpenoid, is the best-selling natural-source
anticancer drug ever produced and one of the most common prescriptions in the treatment of …

Mn-, Fe-, and Co-catalyzed radical hydrofunctionalizations of olefins

SWM Crossley, C Obradors, RM Martinez… - Chemical …, 2016 - ACS Publications
Cofactor-mimetic aerobic oxidation has conceptually merged with catalysis of syngas
reactions to form a wide range of Markovnikov-selective olefin radical …

Carbon–carbon bond forming reactions via photogenerated intermediates

D Ravelli, S Protti, M Fagnoni - Chemical reviews, 2016 - ACS Publications
The present review offers an overview of the current approaches for the photochemical and
photocatalytic generation of reactive intermediates and their application in the formation of …

Photochemical approaches to complex chemotypes: applications in natural product synthesis

MD Karkas, JA Porco Jr, CRJ Stephenson - Chemical Reviews, 2016 - ACS Publications
The use of photochemical transformations is a powerful strategy that allows for the formation
of a high degree of molecular complexity from relatively simple building blocks in a single …

Remote C–H functionalization via selective hydrogen atom transfer

LM Stateman, KM Nakafuku, DA Nagib - Synthesis, 2018 - thieme-connect.com
The selective functionalization of remote C–H bonds via intramolecular hydrogen atom
transfer (HAT) is transformative for organic synthesis. This radical-mediated strategy …

State-of-the-art biocatalysis

JB Pyser, S Chakrabarty, EO Romero… - ACS central …, 2021 - ACS Publications
The use of enzyme-mediated reactions has transcended ancient food production to the
laboratory synthesis of complex molecules. This evolution has been accelerated by …

Strategic application of C–H oxidation in natural product total synthesis

I Bakanas, RF Lusi, S Wiesler… - Nature Reviews …, 2023 - nature.com
The oxidation of unactivated C–H bonds has emerged as an effective tactic in natural
product synthesis and has altered how chemists approach the synthesis of complex …

Dual electrocatalysis enables enantioselective hydrocyanation of conjugated alkenes

L Song, N Fu, BG Ernst, WH Lee, MO Frederick… - Nature …, 2020 - nature.com
Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive
compounds. Enantioselective alkene hydrocyanation represents a convenient and efficient …