Oxidative stress, free radicals and antioxidants: Potential crosstalk in the pathophysiology of human diseases

P Chaudhary, P Janmeda, AO Docea… - Frontiers in …, 2023 - frontiersin.org
Introduction: Free radicals are reactive oxygen species that constantly circulate through the
body and occur as a side effect of many reactions that take place in the human body. Under …

[HTML][HTML] Metformin: Is it a drug for all reasons and diseases?

CR Triggle, I Mohammed, K Bshesh, I Marei, K Ye… - Metabolism, 2022 - Elsevier
Metformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the
first-choice drug used daily by approximately 150 million people. An accumulation of …

NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential

N Xie, L Zhang, W Gao, C Huang, PE Huber… - Signal transduction and …, 2020 - nature.com
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …

NAD (H) and NADP (H) redox couples and cellular energy metabolism

W Xiao, RS Wang, DE Handy… - Antioxidants & redox …, 2018 - liebertpub.com
Significance: The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and
NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular …

The redox role of G6PD in cell growth, cell death, and cancer

HC Yang, YH Wu, WC Yen, HY Liu, TL Hwang, A Stern… - Cells, 2019 - mdpi.com
The generation of reducing equivalent NADPH via glucose-6-phosphate dehydrogenase
(G6PD) is critical for the maintenance of redox homeostasis and reductive biosynthesis in …

The genetics of aging: a vertebrate perspective

PP Singh, BA Demmitt, RD Nath, A Brunet - Cell, 2019 - cell.com
Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism

R Tao, Y Zhao, H Chu, A Wang, J Zhu, X Chen, Y Zou… - Nature …, 2017 - nature.com
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essential for
biosynthetic reactions and antioxidant functions; however, detection of NADPH metabolism …

A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

JM Ghergurovich, JC García-Cañaveras… - Nature chemical …, 2020 - nature.com
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the
oxidative pentose phosphate pathway to make reduced nicotinamide adenine dinucleotide …

Where metabolism meets senescence: focus on endothelial cells

J Sabbatinelli, F Prattichizzo, F Olivieri… - Frontiers in …, 2019 - frontiersin.org
Despite the decline in their proliferative potential, senescent cells display a high metabolic
activity. Senescent cells have been shown to acquire a more glycolytic state even in …

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

CE Xirouchaki, Y Jia, MJ McGrath, S Greatorex… - Science …, 2021 - science.org
Reactive oxygen species (ROS) generated during exercise are considered integral for the
health-promoting effects of exercise. However, the precise mechanisms by which exercise …