Temporal changes in blood flow are commonly observed in malignant tumours, but the
evolutionary causes and consequences are rarely considered. We propose that stochastic …

There has been a resurgence of interest in non-equilibrium stochastic processes in recent
years, driven in part by the observation that the number of molecules (genes, mRNA …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Bi-phasic or diauxic growth is often observed when microbes are grown in a chemically
defined medium containing two sugars (for example glucose and lactose). Typically, the two …

Population heterogeneity is omnipresent in all bioprocesses even in homogenous
environments. Its origin, however, is only so well understood that potential strategies like bet …

The emergence of acquired drug resistance in cancer represents a major barrier to
treatment success. While research has traditionally focused on genetic sources of …

Simple Summary The importance of stem cells for regenerative medicine has grown
significantly in recent years. This is because stem cells can differentiate into multiple cell …

Microbes are constantly confronted with changes and challenges in their environment. A
proper response to these environmental cues is needed for optimal cellular functioning and …

Cancers are complex dynamic systems that undergo evolution and selection. Personalized
medicine approaches in the clinic increasingly rely on predictions of tumour response to one …

Intra-tumour heterogeneity is a leading cause of treatment failure and disease progression
in cancer. While genetic mutations have long been accepted as a primary mechanism of …