Tobacco use is strongly associated with a variety of psychiatric disorders. Smokers are more
likely than non-smokers to meet current criteria for mental health conditions, such as mood …

Bupropion, introduced as an antidepressant in the 1980s, is also effective as a smoking
cessation aid and is beneficial in the treatment of methamphetamine addiction, cocaine …

Although the Torpedo nicotinic acetylcholine receptor (nAChR) reconstituted into
phosphatidylcholine (PC) membranes lacking cholesterol and anionic lipids adopts a …

The FDA-approved antidepressant and smoking cessation drug bupropion is known to
inhibit dopamine and norepinephrine reuptake transporters, as well as nicotinic …

Nicotinic acetylcholine receptors (nAChRs) fulfill a variety of functions making identification
and analysis of nAChR subtypes a challenging task. Traditional instruments for nAChR …

For decades, the development of selective compounds has been the main goal for chemists
and biologists involved in drug discovery. However, diverse lines of evidence indicate that …

Introduction: The vast majority of tobacco smokers seeking to quit will relapse within the first
month of abstinence. Currently available smoking cessation agents have limited utility in …

Although the activity of the nicotinic acetylcholine receptor (nAChR) is exquisitely sensitive
to its membrane environment, the underlying mechanisms remain poorly defined. The …

Diseases associated with nicotine dependence in the form of habitual tobacco use are a
major cause of premature death in the United States. The majority of tobacco smokers will …

Pentameric ligand-gated ion channels (pLGICs), also called Cys-loop receptors in
eukaryotic superfamily members, play diverse roles in neurotransmission and serve as …