Adrenomedullin (ADM) is a 52-amino acid peptide with structural homology to calcitonin
gene-related peptide (CGRP) initially isolated from human pheochromocytoma. ADM is …

Our conceptual understanding of the molecular architecture of G-protein coupled receptors
(GPCRs) has transformed over the last decade. Once considered as largely independent …

OBJECTIVES We sought to assess plasma concentrations of the amino (N)-terminal portion
of pro-brain natriuretic peptide (N-BNP) and adrenomedullin for prediction of adverse …

Background—Persistent inflammation appears to play a role in the development of heart
failure (HF). Osteoprotegerin (OPG), the receptor activator of nuclear factor-κB (RANK), and …

Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to
encompass novel protein interactions that underlie both cell-surface receptor expression …

Adrenomedullin (AM) is a recently discovered regulatory peptide involved in many functions
including vasodilatation, electrolyte balance, neurotransmission, growth, and hormone …

Heart failure is a complex medical syndrome that is attributed to a number of risk factors;
nevertheless, its clinical presentation is quite similar among the different etiologies. Heart …

Adrenomedullin (AM) is a potent vasoactive peptide and plays an important role in
cardiovascular function. In this study, we delivered the AM gene locally into the heart, using …

Adrenomedullin (AM) is a peptide that possesses potentially beneficial properties. Since the
initial discovery of the peptide by Kitamura et al. in 1993, the literature has been awash with …

Objective. Notch signaling is crucial for cell-to-cell interaction during cardiovascular
development and may influence differentiation, proliferation, and apoptotic events. We …