Hypothalamic AgRP and POMC neurons are conventionally viewed as the yin and yang of
the body's energy status, since they act in an opposite manner to modulate appetite and …

TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

The melanocortin system plays a critical role in the central regulation of food intake and
energy balance. This system consists of neurons producing pro-opiomelanocortin (POMC) …

The hypothalamus contains a remarkable diversity of neurons that orchestrate behavioural
and metabolic outputs in a highly plastic manner. Neuronal diversity is key to enabling …

The hypothalamus is an evolutionarily conserved endocrine interface that, among other
roles, links central homeostatic control to adaptive bodily responses by releasing hormones …

Despite the crucial physiological processes governed by neurons in the hypothalamic
arcuate nucleus (ARC), such as growth, reproduction and energy homeostasis, the …

Proopiomelanocortin (POMC) neurons of the hypothalamic arcuate nucleus are essential to
regulate food intake and energy balance. However, the ontogenetic transcriptional programs …

Imprinted genes with parental-biased allelic expression are frequently co-regulated and
enriched in common biological pathways. Here, we functionally characterize a large cluster …

The tuberal hypothalamus regulates a range of crucial physiological processes, including
energy homeostasis and metabolism. In this Review, we explore the intricate molecular …

Gonadotropin releasing hormone (GnRH) neurons are hypothalamic neuroendocrine cells
that control sexual reproduction. During embryonic development, GnRH neurons migrate …