Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Skeletal muscle contraction is essential for the movement of our musculoskeletal system.
Tendons and ligaments that connect the skeletal muscles to bones in the correct position at …

Each skeletal muscle acquires its unique size before birth, when terminally differentiating
myocytes fuse to form a defined number of multinucleated myofibres. Although mice in which …

Gene-targeted knockout technologies are invaluable tools for understanding the functions of
genes in vivo. CRISPR/Cas9 system of RNA-guided genome editing is revolutionizing …

Fusion of nascent myoblasts to pre-existing myofibres is critical for skeletal muscle growth
and repair. The vast majority of molecules known to regulate myoblast fusion are necessary …

Tendon, ligament, and skeletal muscle are highly organized tissues that largely rely on a
hierarchical collagenous matrix to withstand high tensile loads experienced in activities of …

Due to its amenability to manipulations, to live observation and its striking similarities to
mammals, the chicken embryo has been one of the major animal models in biomedical …

Skeletal muscle specification and morphogenesis during early development are critical for
normal physiology. In addition to mediating locomotion, skeletal muscle is a secretory organ …

Skeletal myogenesis is dynamic, and it involves cell-shape changes together with cell fusion
and rearrangements. However, the final muscle arrangement is highly organized with …

A critical stage in the development of all vertebrate embryos is the generation of the body
plan and its subsequent patterning and regionalisation along the main anterior-posterior …